An improved procedure for synthesis of DL-4-hydroxy-3-methoxymandelic acid (DL-""vanillyl""-mandelic acid, VMA)
نویسندگان
چکیده
منابع مشابه
Urinary vanillyl-mandelic acid (VMA) excretion by chronically anaemic children.
Hypoxia has been regarded as one of the many factors stimulating augmented catecholamine biosynthesis (Vogt, 1960). Plasma levels of epinephrine and norepinephrine were found to be increased in newborns with the respiratory distress syndrome or placental insufficiency (Cheek, Malinek, and Fraillon, 1963). Infants with severe heart failure eliminate in the urine twice as much metanephrine, norme...
متن کاملPaper-chromatographic quantitation of 4-hydroxy-3-methoxymandelic acid (VMA) in urine.
We describe a quantitative paperchromatographic method for assaying 3-methoxy-4-hydroxymandelic acid (VMA) in urine. VMA is extracted from acidified urine into ethyl acetate, separated from interfering amine, acid, and alcoholic metabolites by paper chromatography, and reacted with diazotized p-nitroaniline. The colored derivative is eluted and spectrophotometrically analyzed. Recoveries of rep...
متن کاملDEVELOPMENT OF A METHOD FOR THE DETERMINATION OF 4-HYDROXY-3-METHOXYMANDELIC ACID (VANILLYLMANDELIC ACID) IN URINE BY PAPER CHROMATOGRAPHY
We have developed a simple and precise paper chromatographic method for the determination of 4-hydroxy-3-methoxymandelic acid (VMA) in urine. Concentrations of VMA in patients with neuroblastoma were increased in comparison to controls. The linearity was excellent in the concentration range tested. The within-assay coefficient of variation for control and patient urine was less than 2.2%. ...
متن کاملThe estimation of 4-hydroxy-3-methoxymandelic acid in urine.
Armstrong & McMillan (1957) identified 4hydroxy-3-methoxymandelic acid (vanilmandelic acid) in normal human urine and demonstrated that increased quantities were excreted after noradrenaline infusion and by patients with the catecholamine-secreting tumour, phaeochromocytoma. Subsequent work has established that 3methoxylation followed by oxidative deamination to 4-hydroxy-3-methoxymandelic acid...
متن کاملSimultaneous liquid-chromatographic analysis for 4-hydroxy-3-methoxymandelic acid and 4-hydroxy-3-methoxyphenylacetic acid in urine.
We describe a rapid, reliable "high-performance" liquid-chromatographic method of simultaneously analyzing for 4-hydroxy-3-methoxymandelic acid (I) and 4-hydroxy-3-methoxyphenylacetic acid (II) in urine. Paired-ion chromatography and amperometric detection are used in the method. A 5-mL aliquot of urine is adjusted to pH 6.1 and subjected to anion-exchange chromatography (Dowex AG 1-X4, 1.8 X 0...
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ژورنال
عنوان ژورنال: Journal of Research of the National Bureau of Standards Section A: Physics and Chemistry
سال: 1974
ISSN: 0022-4332
DOI: 10.6028/jres.078a.024